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M94A3129.TXT
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Document 3129
DOCN M94A3129
TI Natural history of HIV-1 & HIV-2 in cohort of W. African females.
DT 9412
AU Marlink R; Traore I; Thior I; Ndoye I; Essex M; Mboup S; Kanki P;
Harvard AIDS Institute, Harvard School of Public Health,; Cambridge, MA
02138.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):147 (abstract no. PB0015). Unique
Identifier : AIDSLINE ICA10/94369446
AB OBJECTIVE: A large cohort of female sex workers has been followed since
1985 in Dakar, Senegal, to determine the clinical and immunologic
outcome of HIV-1 and HIV-2 disease. METHODS: Women enrolling in an
outpatient clinic in Dakar were screened for HIV status after informed
consent. Prevalent seropositives and known seroconverters, along with a
stratified seronegative group, were asked to enroll in a clinical
follow-up study if asymptomatic. RESULTS: Incidence of AIDS according to
person-years observed (PYO): TABULAR DATA, SEE ABSTRACT VOLUME.
Kaplanmeir analysis shows that the HIV-2 seroprevalent and
seroconverters have a significantly longer disease-free time to AIDS or
CDCIV disease than the HIV-1 seroprevalent or seroconverters
(Wilcoxon-Gehantest, p < .05). DISCUSSION AND CONCLUSIONS: The rate of
disease development with HIV-2 is significantly less than that of HIV-1
in the same region and population. This difference in clinical latency
has important implications for the individual patient and modeling the
epidemic for this area.
DE Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY Comparative Study
Female Human HIV Seropositivity/*EPIDEMIOLOGY *HIV Seroprevalence
*HIV-1 *HIV-2 Incidence Prevalence Prostitution
Senegal/EPIDEMIOLOGY Survival Analysis *Women MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).